How recently have you used Wine? Adobe CS6 version 13.0 has been tested with the 3.0 version of Wine and has a Silver rating (There are Gold and Platinum ratings above that). But, according to the test write-up, the only thing that didn’t work was reading camera RAW data. So, YMMV.

Why do you need this? Virtualbox supports 3D accelerated graphics to the guest OS. If you need direct hardware access, you might be better of dual booting.

Ubuntu is still a reasonable choice for beginners. Depending how long ago you tried it, the interface may have changed from what you were using. But, it is actually fairly intuitive, so the learning curve shouldn’t be too bad.

If you want a really cool looking desktop, you may want Compiz Fusion installed. It’s a fancy 3D window compositor. I don’t know of any distributions that have it enabled by default, but several have it available, including Ubuntu, which uses Compiz Core (the stripped-down model LOL!) to render some of its effects.