Almost as efficient and quick way to wake up as a kick to the groin. Just imagine the alarm clocks you could make for people that have difficulties getting up in the morning...
That might be useful as the initial power supply for feeding high voltage capacitors as part of a taser. I can't think of any other way I'd use it.
Adjustable voltage down to 0V might be useful, but with it adjustable all the way up to 1250V, I could see adjusting it way too far and having a very bad time because of it.